(6-Benzyloxy-4-methyl-indol-1-yl)-acetic acid tert-butyl ester → (6-Hydroxy-4-methyl-indol-1-yl)-acetic acid tert-butyl ester

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Reaction Steps

A solution of (6-benzyloxy-4-methyl-indol-1-yl)-acetic acid tert-butyl ester (140 mg, 0.4 mmol) in ethanol (14 ml) was hydrogenated over 10% palladium on charcoal (14 mg) at ambient temperature for 3 h. The catalyst was filtered off, the solvent evaporated under reduced pressure to give 100 mg (0.38 mmol, 96%) of the title compound as brown oil which was used in the next step without further purification.

Provenance & Evidence