Lithium Hydroxide → {4-methyl-6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid

HRID 915447Notes

Reaction equation

C([O:5][C:6](=[O:37])[CH2:7][N:8]1[C:16]2[C:11](=[C:12]([CH3:36])[CH:13]=[C:14]([O:17][CH2:18][C:19]3[N:20]([CH3:35])[N:21]=[C:22]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]([F:34])([F:33])[F:32])=[CH:26][CH:25]=4)[CH:23]=3)[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[CH3:36][C:12]1[CH:13]=[C:14]([O:17][CH2:18][C:19]2[N:20]([CH3:35])[N:21]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:31]([F:33])([F:34])[F:32])=[CH:26][CH:25]=3)[CH:23]=2)[CH:15]=[C:16]2[C:11]=1[CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:37])=[O:5]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69280239{4-methyl-6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

Product 1

HCID 69283010{4-methyl-6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described for example 1 f], {4-methyl-6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {4-methyl-6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as colorless solid.

Sources & evidence

ORD record: ord-01f50ee925ee4cb38fc76424d8ec689f
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07265149B2

Reaction notes

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