Lithium Hydroxide → HCID 69282796, compound

HRID 915463Notes

Reaction equation

C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[N:18]([CH3:33])[N:19]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=4)[CH:21]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[F:28][C:25]1[CH:26]=[CH:27][C:22]([C:20]2[CH:21]=[C:17]([CH2:16][O:15][C:12]3[CH:13]=[C:14]4[C:9]([CH:8]=[CH:7][N:6]4[CH2:5][C:4]([OH:34])=[O:3])=[CH:10][CH:11]=3)[N:18]([CH3:33])[N:19]=2)=[CH:23][C:24]=1[C:29]([F:30])([F:31])[F:32]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69282809{6-[5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester

Product 1

HCID 69282796HCID 69282796, compound

Procedure

In analogy to the procedure described for example 1 f], {6-[5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain {6-[5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as brown solid.

Sources & evidence

ORD record: ord-485486c1c360462bb21f6b8258e21249
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07265149B2

Reaction notes

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