Acetonitrile → [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile

HRID 915475Notes

Reaction equation

HRID 915475 reaction equation
Cl[CH2:2][C:3]1[N:7]([CH2:8][C:9]([F:12])([F:11])[F:10])[N:6]=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=2)[CH:4]=1.[C:24](#[N:26])C>[C-]#N.C([N+](CCCC)(CCCC)CCCC)CCC>[F:10][C:9]([F:12])([F:11])[CH2:8][N:7]1[C:3]([CH2:2][C:24]#[N:26])=[CH:4][C:5]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=2)=[N:6]1

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 866006325-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole

Product 1

HCID 86600633[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile

Reagents, catalysts & solvents 1

HCID 165872Tetrabutylammonium CyanideCatalyst

Procedure

In analogy to the procedure described for example 9 b], 5-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole was reacted with tetrabutylammonium cyanide in acetonitrile to give [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile as yellow oil.

Sources & evidence

ORD record
ord-d64685d2c95f4ddea47d637e3e359f93
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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