Lithium Hydroxide → [Rac]-2-{6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2h-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid

HRID 915487Notes

Reaction equation

HRID 915487 reaction equation
C([O:3][C:4](=[O:35])[CH:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH2:17][C:18]3[N:19]([CH3:34])[N:20]=[C:21]([C:23]4[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=4)[CH:22]=3)[CH:14]=2)[CH:9]=[CH:8]1)[CH3:6])C.[Li+].[OH-]>>[CH3:34][N:19]1[C:18]([CH2:17][O:16][C:13]2[CH:14]=[C:15]3[C:10]([CH:9]=[CH:8][N:7]3[CH:5]([CH3:6])[C:4]([OH:35])=[O:3])=[CH:11][CH:12]=2)=[CH:22][C:21]([C:23]2[CH:28]=[CH:27][C:26]([O:29][C:30]([F:32])([F:33])[F:31])=[CH:25][CH:24]=2)=[N:20]1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69282790[Rac]-2-{6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2h-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid ethyl ester

Product 1

HCID 69284534[Rac]-2-{6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2h-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid

Procedure

In analogy to the procedure described in example 1 f], [rac]-2-{6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-{6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid as off-white crystals.

Sources & evidence

ORD record
ord-d74a2ecabb11490694dc886f699d3cc4
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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