HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3,4-Dichlorophenoxy)-1-piperidinepropanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propylcarbamate | HCID 11188863 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(3,4-Dichlorophenoxy)-1-piperidinepropanamine | HCID 11324126 | 73.2% |
Reaction Steps
The product from Step (a) (2 g) was dissolved in dioxane (100 ml) and 6N HCl (100 ml) was added. After 18 hours at room temperature the solvent was evaporated and the resultant solid was dissolved in aqueous NaOH (2M) to pH 11. The solution was extracted with ethyl acetate, the organic phase was dried (MgSO4) and evaporated to leave the title compound as an oil (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265227B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-5804d3a6f85b4ba48421d1f3a3abacda |
| Source note | uspto-grants-2007_09 |