Sodium Hydroxide → HCID 69420218, compound

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	4-(3,4-Dichlorophenoxy)piperidine	HCID 3732042	—
Reactant	2-Propenamide, N-[(4-methylphenyl)sulfonyl]-	HCID 11746302	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 69420218	HCID 69420218	17.4%

Reaction Steps

4-Methyl-N-(1-oxo-2-propenyl)-benzenesulfonamide (0.140 g) was dissolved in THF (10 mL) and 4-(3,4-dichlorophenoxy)-piperidine (0.120 g) and NaOH (0.080 g) were added. The reaction mixture was stirred for 72 h. The solvents were evaporated. The residue was purified by HPLC (gradient Ammonium acetate/Acetonitrile 95% to 5%; Xterra column) to give the title compound (40 mg)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07265227B2
Source dataset	uspto-grants-2007_09
ORD ID	ord-318fa01a13ce42dfb32f4d46e9faccfd
Source note	uspto-grants-2007_09