Sodium Hydroxide → HCID 69420218, compound

HRID 915547Notes

Reaction equation

HRID 915547 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([CH:27]=[CH:28][C:29]=1[Cl:30])[O:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[OH-].[Na+]>C1COCC1>[Cl:16][C:17]1[CH:18]=[C:19]([CH:27]=[CH:28][C:29]=1[Cl:30])[O:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:14][CH2:13][C:12]([NH:11][S:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=2)(=[O:10])=[O:9])=[O:15])[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 37320424-(3,4-Dichlorophenoxy)piperidineHCID 117463022-Propenamide, N-[(4-methylphenyl)sulfonyl]-

Product 1

HCID 69420218HCID 69420218, compoundYield 17.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-Methyl-N-(1-oxo-2-propenyl)-benzenesulfonamide (0.140 g) was dissolved in THF (10 mL) and 4-(3,4-dichlorophenoxy)-piperidine (0.120 g) and NaOH (0.080 g) were added. The reaction mixture was stirred for 72 h. The solvents were evaporated. The residue was purified by HPLC (gradient Ammonium acetate/Acetonitrile 95% to 5%; Xterra column) to give the title compound (40 mg)

Workup

  1. customThe solvents were evaporated
  2. customThe residue was purified by HPLC (gradient Ammonium acetate/Acetonitrile 95% to 5%; Xterra column)

Sources & evidence

ORD record
ord-318fa01a13ce42dfb32f4d46e9faccfd
Source dataset
uspto-grants-2007_09
Patent number
US07265227B2

Reaction notes

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