反应详情

11.5 ml of ethyl alcohol and 2.9 ml of thionyl chloride (SOCl2) were placed in a flask under an inert atmosphere. It was stirred for 15 min and 1.67 g (4.56 mmol) of 5-(2,4-difluorophenyl)-3-iodo-salicylic acid was added. It was stirred continuously at room temperature until no evolution was observed by HPLC. The solvent was evaporated at low pressure and extracted with ethyl acetate. A crude of 97% purity was obtained and then purified by chromatography on silica gel.

1. stirringIt was stirred continuously at room temperature until no evolution
2. customThe solvent was evaporated at low pressure
3. extractionextracted with ethyl acetate
4. customA crude of 97% purity was obtained
5. custompurified by chromatography on silica gel