Ethanol → Ethyl 5-(2,4-difluorophenyl)-3-iodo-salicylate

Beteiligte Stoffe

Reaktionsschritte

11.5 ml of ethyl alcohol and 2.9 ml of thionyl chloride (SOCl2) were placed in a flask under an inert atmosphere. It was stirred for 15 min and 1.67 g (4.56 mmol) of 5-(2,4-difluorophenyl)-3-iodo-salicylic acid was added. It was stirred continuously at room temperature until no evolution was observed by HPLC. The solvent was evaporated at low pressure and extracted with ethyl acetate. A crude of 97% purity was obtained and then purified by chromatography on silica gel.

Herkunft & Nachweise