反应详情

This compound was obtained by saponification of the ester of the previous example (Example 16) (ethyl 2′,4′-difluoro-4-methoxy-5-iodo-[1,1′]biphenyl-3-carboxylate). The ester (200 mg, 0.48 mmol) was dissolved in 20 ml of ethanol and a 2.5 N solution of NaOH for 2 hr. After cooling, the mixture was acidified with hydrochloric acid and extracted with dichloromethane. After the work-up, a crude was obtained that was recrystalized from a chloroform/hexane mixture.

1. temperatureAfter cooling
2. extractionextracted with dichloromethane
3. customAfter the work-up, a crude was obtained
4. customthat was recrystalized from a chloroform/hexane mixture