Hydrochloric Acid → HCID 11452095, compound

HRID 915616Notes

Reaction equation

HRID 915616 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([I:15])[C:12]([O:16][CH3:17])=[C:11]([C:18]([O:20]CC)=[O:19])[CH:10]=1.[OH-].[Na+].Cl>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([I:15])[C:12]([O:16][CH3:17])=[C:11]([C:18]([OH:20])=[O:19])[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11166000HCID 11166000, compound

Product 1

HCID 11452095HCID 11452095, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was obtained by saponification of the ester of the previous example (Example 16) (ethyl 2′,4′-difluoro-4-methoxy-5-iodo-[1,1′]biphenyl-3-carboxylate). The ester (200 mg, 0.48 mmol) was dissolved in 20 ml of ethanol and a 2.5 N solution of NaOH for 2 hr. After cooling, the mixture was acidified with hydrochloric acid and extracted with dichloromethane. After the work-up, a crude was obtained that was recrystalized from a chloroform/hexane mixture.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with dichloromethane
  3. customAfter the work-up, a crude was obtained
  4. customthat was recrystalized from a chloroform/hexane mixture

Sources & evidence

ORD record
ord-b696b3ae137545cda3c64a3d8b6fe284
Source dataset
uspto-grants-2007_09
Patent number
US07265245B2

Reaction notes

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