反应详情

Dissolve 5-bromomethyl-2-phenyloxazole (1.17 g, 4.94 mmol) in dimethylformamide (15 mL) and add dropwise to a solution of potassium phthalimide (1.1 g, 5.93 mmol) in dimethylformamide (15 mL). Stir the reaction under nitrogen at room temperature overnight, concentrate to remove dimethylformamide, dissolve in ethyl acetate (75 mL), wash with saturated Na2CO3 (50 mL), and brine (75 mL). Dry the organic phase (Na2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 4:1 to 1:1 Hex/ethyl acetate to afford 1.5 g of 2-(2-phenyloxazol-5-ylmethyl)isoindole-1,3-dione as an off-white solid. MS: m/e=305 (MH+)

1. customthe reaction under nitrogen at room temperature overnight
2. concentrationconcentrate
3. customto remove dimethylformamide
4. dissolutiondissolve in ethyl acetate (75 mL)
5. washwash with saturated Na2CO3 (50 mL), and brine (75 mL)
6. dry with materialDry the organic phase (Na2SO4)
7. filtrationfilter
8. concentrationconcentrate