反应详情

Heat a suspension of 2-(2-phenyloxazol-5-ylmethyl)isoindole-1,3-dione (1.5 g, 4.94 mmol) in 6N HCl (75 mL) at reflux for 5 days. Cool, basify with 3 N sodium hydroxide, and extract with methylene chloride (2×150 mL). Dry the organic phase (Na2SO4), filter, and concentrate to afford 400 mg of the title compound as a yellow oil. MS: m/e=175 (MH+).

1. temperatureHeat
2. temperatureat reflux for 5 days
3. temperatureCool
4. extractionextract with methylene chloride (2×150 mL)
5. dry with materialDry the organic phase (Na2SO4)
6. filtrationfilter
7. concentrationconcentrate