反应详情

Prepare a cold (0° C.) solution of (5-phenyl-thiazol-4-yl)-methanol (1.4 g, 7.3 mmol) in CH3CN (50 mL). Add PPh3 (2.6 g, 9.7 mmol) and CBr4 (3.2 g, 9.7 mmol). Stir the reaction at 0° C. for 3 hours, allow to warm to room temperature and then concentrate in vacuo to an oil. Chromatograph (silica gel, 4:1 Hex/ethyl acetate) to afford the title compound (400 mg). 1H NMR (CDCl3) δ 8.80 (s, 1H), 7.40-7.60 (m, 5H), 4.65 (s, 2H).

1. customthe reaction at 0° C. for 3 hours
2. concentrationconcentrate in vacuo to an oil