反应详情

Prepare a cold (0° C.) solution of potassium phthalimide (350 mg, 1.8 mmol) in dimethylformamide (25 mL). Add dropwise 4-bromomethyl-5-phenyl-thiazole (400 mg, 1.6 mmol) in dimethylformamide (10 mL). Warm the reaction to room temperature, stir for 3 hours and then concentrate. Dissolve the residue in ethyl acetate (100 mL), wash with saturated Na2CO3 (50 mL) and brine (50 mL), then dry (Na2SO4), filter and concentrate to a brown residue. Chromatograph (silica gel, 4:1 hexane/ethyl acetate) to afford 2-(5-phenylthiazol-4-ylmethyl)isoindole-1,3-dione (270 mg).

1. temperatureWarm
2. customthe reaction to room temperature
3. concentrationconcentrate
4. dissolutionDissolve the residue in ethyl acetate (100 mL)
5. washwash with saturated Na2CO3 (50 mL) and brine (50 mL)
6. dry with materialdry (Na2SO4)
7. filtrationfilter
8. concentrationconcentrate to a brown residue