反应详情

Prepare a cold (0° C.) solution of 2-(5-phenylthiazol-4-ylmethyl)isoindole-1,3-dione (260 mg, 0.8 mmol) in methanol (15 mL). Add hydrazine (0.05 mL, 1.6 mmol). Warm the reaction to room temperature and stir overnight. Concentrate the reaction in vacuo. Dissolve the residue in ethyl acetate (25 mL) and filter to remove solids. Concentrate the filtrate in vacuo to an oil. Chromatograph (silica gel, 93:6:1 CHCl3/MeOH/concentrated NH4OH) to afford the title compound (130 mg). 1H NMR (CDCl3) δ 8.75 (s, 1H), 7.39-7.49 (m, 5H), 4.00 (s, 2H), 1.62 (br s, 2H).

1. temperatureWarm
2. customthe reaction to room temperature
3. concentrationConcentrate
4. customthe reaction in vacuo
5. filtrationfilter
6. customto remove solids
7. concentrationConcentrate the filtrate in vacuo to an oil