反应详情

Prepare a solution of 2-(5-phenylthiophen-3-ylmethyl)isoindole-1,3-dione (565 mg, 1.77 mmol) in methanol (57 mL). Add hydrazine (0.35 mL, 11.14 mmol). Heat the mixture to reflux. After stirring for 1 hour, cool the mixture to room temperature and concentrate. Perform flash chromatography on silica gel eluting with 50:40:9:1 methylene chloride/CHCl3/MeOH/concentrated NH4OH to afford 280 mg of the title compound as a yellow solid. MS: m/e=190 [MH+].

1. temperatureHeat the mixture
2. temperatureto reflux
3. concentrationconcentrate