HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → (5-Phenylthiophen-3-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2-(5-Phenylthiophen-3-ylmethyl)isoindole-1,3-dione | HCID 69129971 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (5-Phenylthiophen-3-yl)methanamine | HCID 69129967 | 83.6% |
Reaction Steps
Prepare a solution of 2-(5-phenylthiophen-3-ylmethyl)isoindole-1,3-dione (565 mg, 1.77 mmol) in methanol (57 mL). Add hydrazine (0.35 mL, 11.14 mmol). Heat the mixture to reflux. After stirring for 1 hour, cool the mixture to room temperature and concentrate. Perform flash chromatography on silica gel eluting with 50:40:9:1 methylene chloride/CHCl3/MeOH/concentrated NH4OH to afford 280 mg of the title compound as a yellow solid. MS: m/e=190 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265246B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-451f52bb10c94aa1b150746b25abd3d0 |
| Source note | uspto-grants-2007_09 |