Ethyl isocyanate → HCID 87825103, compound

HRID 915744Notes

Reaction equation

HRID 915744 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]([CH2:12][CH2:13][F:14])[CH2:7][NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.C(N(CC)CC)C.[CH2:24]([N:26]=[C:27]=[O:28])[CH3:25]>C(#N)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]([CH2:12][CH2:13][F:14])[CH2:7][N:8]([C:27]([NH:26][CH2:24][CH3:25])=[O:28])[S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 8022Ethyl isocyanateHCID 8471TriethylamineHCID 11161396HCID 11161396, compound

Product 1

HCID 87825103HCID 87825103, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 500 mg of the compound of Example 1 dissolved in 2.5 ml of acetonitrile there are added 0.5 ml of triethylamine and 2.5 ml of ethyl isocyanate. The reaction mixture is stirred at ambient temperature for 5 hours. The solvent is then removed under reduced pressure. The residue is taken up in 10 ml of acetone; charcoal is added to the resulting solution, which is then filtered; water is then added to the filtrate. The precipitate obtained is collected by filtration, washed with water and dried.

Workup

  1. customThe solvent is then removed under reduced pressure
  2. additioncharcoal is added to the resulting solution, which
  3. filtrationis then filtered
  4. additionwater is then added to the filtrate
  5. customThe precipitate obtained
  6. filtrationis collected by filtration
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-aaf2ca43ee7946c8bf3f5ee283305f5e
Source dataset
uspto-grants-2007_09
Patent number
US07268129B2

Reaction notes

Loading…