2-Methoxybenzoic acid → 2-Methoxybenzoyl chloride

HRID 915908Notes

Reaction equation

HRID 915908 reaction equation
S(Cl)([Cl:3])=O.[C:5]([OH:15])(=O)[C:6]1[C:7]([O:12][CH3:13])=[CH:8][CH:9]=[CH:10][CH:11]=1>>[C:5]([Cl:3])(=[O:15])[C:6]1[C:7]([O:12][CH3:13])=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 113702-Methoxybenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 889692-Methoxybenzoyl chloride

Procedure

A 1 ml (13.7 mmol) thionyl chloride solution of 136 mg (0.89 mmol) of o-anisic acid was heated under reflux for 2 hours. Then, the excess thionyl chloride was distilled off under reduced pressure to obtain o-anisic acid chloride.

Workup

  1. temperatureunder reflux for 2 hours
  2. distillationThen, the excess thionyl chloride was distilled off under reduced pressure

Sources & evidence

ORD record
ord-7603166fbe3c4febb991b172426d6256
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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