HCID 136005913, compound → HCID 136005835, compound

HRID 915928Notes

Reaction equation

HRID 915928 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[NH:16][C:17](=[O:31])[C:18]3[C:23]([CH:24]4[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)=[N:22][N:21]([CH3:30])[C:19]=3[N:20]=2)=[C:11]([O:32][CH3:33])[CH:10]=1)C1C=CC=CC=1.[H][H]>[C].[Pd].CO>[CH:24]1([C:23]2[C:18]3[C:17](=[O:31])[NH:16][C:15]([C:12]4[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=4[O:32][CH3:33])=[N:20][C:19]=3[N:21]([CH3:30])[N:22]=2)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

5

Reactant 2

HCID 136005913HCID 136005913, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 136005835HCID 136005835, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a 50 ml methanol/50 ml tetrahydrofuran mixed solution of 1.16 g (2.61 mmol) of the compound obtained in Example 35, 300 mg of 5% palladium carbon was added. The mixture was stirred for 3 hours at room temperature at atmospheric pressure in an atmosphere of hydrogen. Then, the catalyst was removed by filtration to obtain 0.92 g (99%) of the captioned compound.

Workup

  1. customThen, the catalyst was removed by filtration

Sources & evidence

ORD record
ord-a6fc4f7137bd497fb0626445a1f98f79
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

Loading…