Hydrochloric Acid → HCID 136005902, compound

HRID 915931Notes

Reaction equation

HRID 915931 reaction equation
CO.[CH:3]1([C:9]2[C:17]3[C:16](=[O:18])[NH:15][C:14]([C:19]4[CH:30]=[CH:29][C:22]([O:23][CH2:24][C:25]([O:27]C)=[O:26])=[CH:21][C:20]=4[O:31][CH3:32])=[N:13][C:12]=3[N:11]([CH3:33])[N:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[OH-].[Na+].Cl>O>[CH:3]1([C:9]2[C:17]3[C:16](=[O:18])[NH:15][C:14]([C:19]4[CH:30]=[CH:29][C:22]([O:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:21][C:20]=4[O:31][CH3:32])=[N:13][C:12]=3[N:11]([CH3:33])[N:10]=2)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 136005779HCID 136005779, compound

Product 1

HCID 136005902HCID 136005902, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

To a 2 ml methanol solution of 127 mg (0.298 mmol) of the compound obtained in Example 40, 372 μl (0.372 mmol) of 1M sodium hydroxide was added, and the mixture was stirred at 50° C. for 1 hour. The reaction mixture was returned to room temperature, and diluted with 5 ml of water. Then, 0.4 ml of 1M hydrochloric acid was slowly added. Precipitated solids were collected by filtration to obtain 85 mg (69%) of the captioned compound.

Workup

  1. customwas returned to room temperature
  2. customPrecipitated solids
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-94822c50534344f783f582fc1313789e
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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