HRID915942

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18677745

未命名化合物

结构：CCOc1cc(Br)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1

HCID136005963

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(N2CCC(N(C)C(=O)OCc3ccccc3)CC2)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1

HCID136333210

未命名化合物

收率 77%

PROCEDURE

实验过程

The same reaction procedure as in Example 27 was performed, except that the compound obtained in Example 85 was used in place of the compound obtained in Example 26, and benzyl methyl(4-piperidinyl)carbamate hydrochloride was used in place of N-methylpiperazine. In this manner, 234 mg (77%) of the captioned compound was obtained.

WORKUP

后处理

customThe same reaction procedure as in Example 27

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0bfbadf1fe8b467f8152c5da47e8a2a7
来源数据集: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07268128B2
来源说明: uspto-grants-2007_09

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[C:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)=[N:15][N:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.Cl.[CH3:29][N:30]([CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)[C:31](=[O:40])[O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH:17]1([C:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:44]5[CH2:43][CH2:42][CH:41]([N:30]([CH3:29])[C:31](=[O:40])[O:32][CH2:33][C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=6)[CH2:46][CH2:45]5)=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[N:14]([CH3:23])[N:15]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1