Piperidin-4-ol → HCID 136005891, compound

HRID 915971Notes

Reaction equation

HRID 915971 reaction equation
[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=4)=[N:11][C:10]=3[N:9]([CH3:27])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:28][CH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23]([N:32]5[CH2:33][CH2:34][CH:29]([OH:28])[CH2:30][CH2:31]5)(=[O:25])=[O:24])=[CH:19][CH:18]=4)=[N:11][C:10]=3[N:9]([CH3:27])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 136005924HCID 136005924, compound

Product 1

HCID 136005891HCID 136005891, compoundYield 62%

Procedure

The same reaction procedure as in Example 49 was performed, except that the compound obtained in Example 181 was used in place of the compound obtained in Example 48, and 4-hydroxypiperidine was used in place of N-methylpiperazine. In this manner, 72 mg (62%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 49

Sources & evidence

ORD record
ord-bafc26ee50c04109b883d79288fb6d5f
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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