Piperidin-4-ol → HCID 136043087, compound

HRID 915974Notes

Reaction equation

HRID 915974 reaction equation
[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][C:18]=4[O:27][CH3:28])=[N:11][C:10]=3[N:9]([CH2:29][CH3:30])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:31][CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23]([N:35]5[CH2:36][CH2:37][CH:32]([OH:31])[CH2:33][CH2:34]5)(=[O:25])=[O:24])=[CH:19][C:18]=4[O:27][CH3:28])=[N:11][C:10]=3[N:9]([CH2:29][CH3:30])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 136005914HCID 136005914, compound

Product 1

HCID 136043087HCID 136043087, compoundYield 91%

Procedure

The same reaction procedure as in Example 49 was performed, except that the compound obtained in Example 206 was used in place of the compound obtained in Example 48, and 4-hydroxypiperidine was used in place of N-methylpiperazine. In this manner, 155 mg (91%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 49

Sources & evidence

ORD record
ord-4d0ef8f5b791445aa8459b25ac004d31
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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