反应详情

To a 2 ml tetrahydrofuran solution of 63 mg (0.15 mmol) of the compound obtained in Example 226, 6 mg of platinum oxide was added, and the mixture was stirred for 3.5 hours in an atmosphere of hydrogen at room temperature and atmospheric pressure. Then, the catalyst was removed by filtration, and the filtrate was distilled under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=1/1) to obtain 52 mg (82%) of the captioned compound.

1. customThen, the catalyst was removed by filtration
2. distillationthe filtrate was distilled under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane=1/1)