Piperazine → HCID 136005895, compound

HRID 915989Notes

Reaction equation

HRID 915989 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[N:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[N:15]=[C:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.[NH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH:17]1([N:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:28]5[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]5)=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[C:14]([CH3:23])=[N:15]2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 136005880HCID 136005880, compound

Product 1

HCID 136005895HCID 136005895, compoundYield 57%

Procedure

The same reaction procedure as in Example 16 was performed, except that the compound obtained in Example 116 was used in place of the compound obtained in Example 15, and piperazine was used in place of N-methylpiperazine. In this manner, 86 mg (57%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 16

Sources & evidence

ORD record
ord-18cf4292b8c949639a7b851c2407b0cc
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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