反应详情

To (1-naphthyl)methyl)(4-methyl-2-nitro-phenyl)amine (1.0021 g, 3.43 mmol), ethanol (5 ml) and 1,4-dioxane (5 ml) were added, and 2.058 M aqueous sodium hydroxide solution (1 ml) was further added, and refluxed in an oil bath. After 15 minutes, it was removed from the oil bath, and zinc powder (897 mg, 13.72 mmol) was fed thereto in portions. Then it was refluxed again in the oil bath for 2 hours. After 2 hours, it was concentrated under reduced pressure, and dissolved in ethyl acetate (50 ml), and washed twice with saturated saline (25 ml). After drying with magnesium sulfate, it was concentrated under reduced pressure and dried to obtain a brown oil of ((1-naphthyl)methyl)(2-amino-4-methyl-phenyl)amine (943.1 mg).

1. temperaturerefluxed in an oil bath
2. temperatureThen it was refluxed again in the oil bath for 2 hours
3. waitAfter 2 hours
4. concentrationit was concentrated under reduced pressure
5. dissolutiondissolved in ethyl acetate (50 ml)
6. washwashed twice with saturated saline (25 ml)
7. dry with materialAfter drying with magnesium sulfate, it
8. concentrationwas concentrated under reduced pressure
9. customdried