Trifluoroacetic acid → HCID 178497634, compound

HRID 916086Notes

Reaction equation

HRID 916086 reaction equation
C([O:5][C:6](=[O:29])[CH2:7][C:8]1[C:16]2[NH:15][C:14]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([O:27][CH3:28])=[O:26])=[N:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:28][O:27][C:25]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[CH2:18][S:17][C:14]1[NH:15][C:16]2[C:8]([CH2:7][C:6]([OH:29])=[O:5])=[CH:9][CH:10]=[CH:11][C:12]=2[N:13]=1)=[O:26]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178497635HCID 178497635, compound

Product 1

HCID 178497634HCID 178497634, compoundYield 64.1%

Procedure

To 2-(2-((2-(methoxycarbonyl)phenyl)methylthio)benzimidazolyl)acetic acid t-butyl ester (1290 mg, 3.13 mmol), trifluoroacetic acid (15 ml) was added, and stirred at room temperature overnight. After the solvent was evaporated, it was dried under reduced pressure to obtain 2-(2-((2-(methoxycarbonyl)phenyl)methylthio)benzimidazolyl)acetic acid (715 mg, yield 64%).

Workup

  1. customAfter the solvent was evaporated
  2. customit was dried under reduced pressure

Sources & evidence

ORD record
ord-f057748241ad484496421c9f34fa44b4
Source dataset
uspto-grants-2007_09
Patent number
US07268145B2

Reaction notes

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