N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine 2,3,4,5,6-pentafluorophenyl ester → N-Fmoc-L-isoleucine

Participants

Reaction Steps

A solution of AE (50 mg; 0.185 mmol) in THF (5 ml) was added with Fmoc-L-Ile-OPfp (211 mg; 0.407 mmol). The solution was refluxed for 48 hrs, the solvent was evaporated, and the residue was purified by chromatography (petroleum ether/ethyl acetate 3:1). 42 mg (37%) of Fmoc-L-Ile-Aloe was isolated as an an orange-coloured powder.

Provenance & Evidence