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HRID916091

反应详情

EQUATION

反应方程式

HRID 916091 的结构方程式

REACTANTS

反应物

1
结构：CC[C@H](C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Oc1c(F)c(F)c(F)c(F)c1F
HCID13585947

Pentafluorophenyl N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-isoleucinate

C27H22F5NO4

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID2724629

N-Fmoc-L-isoleucine

C21H23NO4

收率 37%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of AE (50 mg; 0.185 mmol) in THF (5 ml) was added with Fmoc-L-Ile-OPfp (211 mg; 0.407 mmol). The solution was refluxed for 48 hrs, the solvent was evaporated, and the residue was purified by chromatography (petroleum ether/ethyl acetate 3:1). 42 mg (37%) of Fmoc-L-Ile-Aloe was isolated as an an orange-coloured powder.

WORKUP

后处理

  1. temperatureThe solution was refluxed for 48 hrs
  2. customthe solvent was evaporated
  3. customthe residue was purified by chromatography (petroleum ether/ethyl acetate 3:1)