Sodium Hydroxide → 1-Benzyl-3-aminopyrrolidine

HRID 916243Notes

Reaction equation

HRID 916243 reaction equation
CS(O)(=O)=O.[CH2:6]([N:13]1[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[Na+]>O>[CH2:6]([N:13]1[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10236311HCID 10236311, compound

Product 1

HCID 27566131-Benzyl-3-aminopyrrolidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The 1-benzyl-3-aminopyrrolidine monomethanesulfonate (2 g) was dissolved in water (5 mL). And then 30% sodium hydroxide was added to the solution to isolate 1-benzyl-3-aminopyrrolidine. The solution was extracted with toluene (20 mL) and then concentrated. Thus, oily 1-benzyl-3-aminopyrrolidine (1.10 g) was recovered.

Sources & evidence

ORD record
ord-9b8db400522744ae8a77d05caa394ff2
Source dataset
uspto-grants-2007_09
Patent number
US07268236B2

Reaction notes

Loading…