Hydrochloric Acid → HCID 10329764, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(formylamino)-4-methyl-1H-benzimidazole-7-carbonitrile (4.8 kg), water (46 L) and concentrated hydrochloric acid (17.8 kg) was agitated at about 80° C. for about 1½ h. After the mixture was cooled to about 25° C., a solution of 50% aqueous sodium hydroxide (17.1 kg) and water (64 L) was added. The mixture was cooled to about 25° C. over about 15 min. The mixtures was then filtered and the product was washed with water (50 L). The product was dried in a vacuum tray dryer at 45-50° C. and ca. 40 Torr.

Provenance & Evidence