Hydrochloric Acid → HCID 10329764, compound

HRID 916287Notes

Reaction equation

HRID 916287 reaction equation
C([NH:3][C:4]1[CH:12]=[C:11]([C:13]#[N:14])[C:7]2[NH:8][CH:9]=[N:10][C:6]=2[C:5]=1[CH3:15])=O.Cl.[OH-].[Na+]>O>[NH2:3][C:4]1[CH:12]=[C:11]([C:13]#[N:14])[C:7]2[NH:8][CH:9]=[N:10][C:6]=2[C:5]=1[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10013022HCID 10013022, compound

Product 1

HCID 10329764HCID 10329764, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
80 °C

Procedure

A mixture of 5-(formylamino)-4-methyl-1H-benzimidazole-7-carbonitrile (4.8 kg), water (46 L) and concentrated hydrochloric acid (17.8 kg) was agitated at about 80° C. for about 1½ h. After the mixture was cooled to about 25° C., a solution of 50% aqueous sodium hydroxide (17.1 kg) and water (64 L) was added. The mixture was cooled to about 25° C. over about 15 min. The mixtures was then filtered and the product was washed with water (50 L). The product was dried in a vacuum tray dryer at 45-50° C. and ca. 40 Torr.

Workup

  1. temperatureAfter the mixture was cooled to about 25° C.
  2. temperatureThe mixture was cooled to about 25° C. over about 15 min
  3. filtrationThe mixtures was then filtered
  4. washthe product was washed with water (50 L)
  5. customThe product was dried in a vacuum tray dryer at 45-50° C.

Sources & evidence

ORD record
ord-350ba699bee847a387ef713864d4ebbb
Source dataset
uspto-grants-2007_09
Patent number
US07268255B2

Reaction notes

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