反应详情

1-Cyano-4-fluoronaphthalene (86 mg, 0.5 mmol) was transferred to a Pyrex tube and 3-pyrrolidinol (162 μL, 2.0 mmol) was added followed by toluene (0.5 mL). The tube was capped and the reaction tube was exposed to microwave irradiation (180° C., 5 min). The reaction mixture was concentrated and purified by re-crystallization with EtOH. Yield: 51 mg (43%).

1. additionwas added
2. customThe tube was capped
3. customthe reaction tube was exposed to microwave irradiation (180° C., 5 min)
4. concentrationThe reaction mixture was concentrated
5. custompurified by re-crystallization with EtOH