4-Hydroxypyrrolidine → 4-(3-hydroxypyrrolidin-1-yl)naphthalene-1-carbonitrile

Participants

Reaction Steps

1-Cyano-4-fluoronaphthalene (86 mg, 0.5 mmol) was transferred to a Pyrex tube and 3-pyrrolidinol (162 μL, 2.0 mmol) was added followed by toluene (0.5 mL). The tube was capped and the reaction tube was exposed to microwave irradiation (180° C., 5 min). The reaction mixture was concentrated and purified by re-crystallization with EtOH. Yield: 51 mg (43%).

Provenance & Evidence