1,2,3,6-Tetrahydropyridine → 4-(3,6-dihydro-2H-pyridin-1-yl)naphthalene-1-carbonitrile

HRID 916332Notes

Reaction equation

HRID 916332 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[NH:14]1[CH2:19][CH:18]=[CH:17][CH2:16][CH2:15]1>>[N:14]1([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:15][CH:16]=[CH:17][CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 127501,2,3,6-TetrahydropyridineHCID 27367341-Cyano-4-fluoronaphthalene

Product 1

HCID 116872994-(3,6-dihydro-2H-pyridin-1-yl)naphthalene-1-carbonitrileYield 26%

Procedure

The title compound (7 mg, 26% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 1,2,3,6-tetrahydropyridine (39 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-0194ff9666d74041880720a6a098a601
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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