4-Benzyl-4-piperidinol → 4-(4-Benzyl-4-hydroxypiperidin-1-yl)naphthalene-1-carbonitrile

HRID 916335Notes

Reaction equation

HRID 916335 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[CH2:14]([C:21]1([OH:27])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([C:21]1([OH:27])[CH2:26][CH2:25][N:24]([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:23][CH2:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 981524-Benzyl-4-piperidinolHCID 27367341-Cyano-4-fluoronaphthalene

Product 1

HCID 692270084-(4-Benzyl-4-hydroxypiperidin-1-yl)naphthalene-1-carbonitrileYield 30%

Procedure

The title compound (12 mg, 30% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 4-benzyl-4-hydroxypiperidine (89 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-f0f7da56ccd44775821834b2675cbfd7
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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