HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzyl-4-piperidinol → 4-(4-Benzyl-4-hydroxypiperidin-1-yl)naphthalene-1-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzyl-4-piperidinol | HCID 98152 | — |
| Reactant | 1-Cyano-4-fluoronaphthalene | HCID 2736734 | — |
| Product | 4-(4-Benzyl-4-hydroxypiperidin-1-yl)naphthalene-1-carbonitrile | HCID 69227008 | 30% |
Reaction Steps
The title compound (12 mg, 30% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 4-benzyl-4-hydroxypiperidine (89 mg, 0.468 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07268232B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-f0f7da56ccd44775821834b2675cbfd7 |
| Source note | uspto-grants-2007_09 |