1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → 4-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yl)naphthalene-1-carbonitrile

HRID 916336Notes

Reaction equation

HRID 916336 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[C:14]1([N:20]2[C:24]3([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[C:23](=[O:30])[NH:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[O:30]=[C:23]1[C:24]2([CH2:25][CH2:26][N:27]([C:6]3[C:7]4[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[CH2:28][CH2:29]2)[N:20]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:21][NH:22]1

Participants

3

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 27367341-Cyano-4-fluoronaphthalene

Product 1

HCID 116106434-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yl)naphthalene-1-carbonitrileYield 16%

Procedure

The title compound (7 mg, 16% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 1-phenyl-1,3,8-triazaspiro-[4,5]decan-4-one (108 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-d87c77253972499385b131b313129951
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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