4-Piperidinecarbonitrile, 4-phenyl- → 1-(4-Cyanonaphthalen-1-yl)-4-phenylpiperidine-4-carbonitrile

HRID 916338Notes

Reaction equation

HRID 916338 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[C:14]([C:16]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)#[N:15]>>[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([N:19]2[CH2:18][CH2:17][C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:14]#[N:15])[CH2:21][CH2:20]2)=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 1811384-Piperidinecarbonitrile, 4-phenyl-HCID 27367341-Cyano-4-fluoronaphthalene

Product 1

HCID 692271291-(4-Cyanonaphthalen-1-yl)-4-phenylpiperidine-4-carbonitrileYield 3%

Procedure

The title compound (1 mg, 3% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 4-cyano-4-phenylpiperidine (87 mg, 0.468 mmol).

Sources & evidence

ORD record
ord-76b94e93a69a466abc79b076b156f541
Source dataset
uspto-grants-2007_09
Patent number
US07268232B2

Reaction notes

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