反应详情

温度

80 °C

A suspension of 1-acetylpiperazine (3.85 g, 30 mmol), potassium carbonate (8.3 g, 60 mmol) and 3-bromo-1-propanol (4 ml, 45 mmol) in acetonitrile (30 ml) was heated and stirred at 80° C. for 5 hours. After cooling, the mixture was filtered and the filtrate was evaporated. The residue was purified by column chromatography, eluting with increasingly polar mixtures of methylene chloride and ethanol. The fractions containing the expected product were combined and evaporated to give 3-(4-acetylpiperazin-1-yl)propan-1-ol (3.15 g, 56%).

1. temperaturewas heated
2. temperatureAfter cooling
3. filtrationthe mixture was filtered
4. customthe filtrate was evaporated
5. customThe residue was purified by column chromatography
6. washeluting
7. temperaturewith increasingly polar mixtures of methylene chloride and ethanol
8. additionThe fractions containing the expected product
9. customevaporated