反应详情

A solution of 7-(3-bromopropoxy)-4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxyquinazoline (0.25 g, 0.543 mmol) and 1-acetylpiperazine (0.208 g, 1.63 mmol) in DMF (4 ml) was stirred at 80° C. for 2.5 hours. The volatiles were removed under vacuum and the residue was purified by column chromatography eluting with increasingly polar mixtures of methylene chloride and methanol. The fractions containing the expected product were combined and evaporated. The residue was triturated under diethyl ether and the resulting solid was filtered, washed with diethyl ether and dried under vacuum to give 7-(3-(4-acetylpiperazin-1-yl)propoxy)-4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxyquinazoline (0.25 g, 0.543 mmol).

1. customThe volatiles were removed under vacuum
2. customthe residue was purified by column chromatography
3. washeluting
4. temperaturewith increasingly polar mixtures of methylene chloride and methanol
5. additionThe fractions containing the expected product
6. customevaporated
7. customThe residue was triturated under diethyl ether
8. filtrationthe resulting solid was filtered
9. washwashed with diethyl ether
10. customdried under vacuum