反应详情

温度

85 °C

1-Prop-2-yn-1-ylpiperazine diTFA salt (704 mg, 2 mmol), (prepared as described for the starting material in Example 26), was dissolved in acetonitrile (5 ml). Potassium carbonate (1.38 g, 10 mmol) and 3-bromopropan-1-ol (180 μL, 2 mmol) were added and the mixture heated to 85° C. for 6.5 hours. The reaction mixture was cooled, filtered and concentrated to give an oil. This was triturated with diethyl ether to give a white solid, which was partitioned between dichloromethane and water. The organic phase was then dried (MgSO4) and concentrated to give 3-(4-prop-2-yn-1-ylpiperazin-1-yl)propan-1-ol (286 mg, 79%).

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered
3. concentrationconcentrated
4. customto give an oil
5. customThis was triturated with diethyl ether
6. customto give a white solid, which
7. customwas partitioned between dichloromethane and water
8. dry with materialThe organic phase was then dried (MgSO4)
9. concentrationconcentrated