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5-Bromo-4-methylthiophene-2-carboxylic acid (Nemec, M.; Janda, Miroslav; Srogl, Jan; Stibor, I. Collection of Czechoslovak Chemical Communications (1974), 39(12), 3527–31.) (2.5 g, 11 mmol) was suspended in dichloromethane (25 ml) and dimethylformamide (0.1 ml). Oxalyl chloride (1.1 ml, 13 mmol) was added and the mixture was allowed to stir at ambient temperature for 2 hours. The solvent was evaporated and the crude acid chloride was dried under vacuum. The acid chloride was dissolved in a mixture of acetonitrile (20 ml), tetrahydrofuran (20 ml) and triethylamine (2.0 ml, 14 mmol) and the mixture was cooled in an ice-bath. A solution of (trimethylsilyl)diazomethane (8.5 ml) in hexane (2.0M, 17 mmol) was added dropwise and the mixture allowed to stir in an ice-bath for 20 hours. The solvent was evaporated and the residue partitioned between 1N hydrochloric acid and ethyl acetate. The organic layer was separated, dried over magnesium sulfate and then evaporated to leave a yellow solid. The crude alpha-diazoketone was dissolved in a mixture of benzyl alcohol (10 ml) and 2,4,6-trimethylpyridine (10 ml) and heated to 180 C for 2 hours. The mixture was allowed to cool and then purified directly by flash chromatography on silica eluting with a mixture of 10% ethyl acetate in iso-hexane to afford benzyl (5-bromo-4-methyl-2-thienyl)acetate (0.982 g) as a dark yellow oil

1. customThe solvent was evaporated
2. dry with materialthe crude acid chloride was dried under vacuum
3. temperaturethe mixture was cooled in an ice-bath
4. stirringto stir in an ice-bath for 20 hours
5. customThe solvent was evaporated
6. customthe residue partitioned between 1N hydrochloric acid and ethyl acetate
7. customThe organic layer was separated
8. dry with materialdried over magnesium sulfate
9. customevaporated
10. customto leave a yellow solid
11. temperatureheated to 180 C for 2 hours
12. temperatureto cool
13. custompurified directly by flash chromatography on silica eluting with a mixture of 10% ethyl acetate in iso-hexane