Ammonia → HCID 57503303, compound

HRID 916647Notes

Reaction equation

HRID 916647 reaction equation
[NH3:1].C([O:4][C:5]([C:7]1[N:8]=[C:9]2[C:14]([CH2:15][CH2:16][CH3:17])=[C:13]([CH2:18][N:19]3[CH:23]=[CH:22][N:21]=[C:20]3[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[N:25]=3)[N:12]=[CH:11][N:10]2[CH:31]=1)=O)C>CCO>[F:30][C:26]1[N:25]=[C:24]([C:20]2[N:19]([CH2:18][C:13]3[N:12]=[CH:11][N:10]4[CH:31]=[C:7]([C:5]([NH2:1])=[O:4])[N:8]=[C:9]4[C:14]=3[CH2:15][CH2:16][CH3:17])[CH:23]=[CH:22][N:21]=2)[CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11361822HCID 11361822, compound

Product 1

HCID 57503303HCID 57503303, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Ammonia gas is passed through a stirred solution of 7-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-8-propyl-imidazo[1,2-c]pyrimidine-2-carboxylic acid ethyl ester (110, above) (1 mmol) in EtOH (7 ml) in a sealed tube for 20 minutes at 0° C. The tube is then sealed and heated at 90° C. for 2 days. The solvent is evaporated and the residue (128) is used directly in the next step without further purification.

Workup

  1. customThe tube is then sealed
  2. customThe solvent is evaporated
  3. customthe residue (128) is used directly in the next step without further purification

Sources & evidence

ORD record
ord-9ccd4c77d01c451bb15dfebcc8ddd88d
Source dataset
uspto-grants-2007_09
Patent number
US07271170B2

Reaction notes

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