Ammonia → HCID 57503303, compound

Participants

Reaction Conditions

Reaction Steps

Ammonia gas is passed through a stirred solution of 7-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-8-propyl-imidazo[1,2-c]pyrimidine-2-carboxylic acid ethyl ester (110, above) (1 mmol) in EtOH (7 ml) in a sealed tube for 20 minutes at 0° C. The tube is then sealed and heated at 90° C. for 2 days. The solvent is evaporated and the residue (128) is used directly in the next step without further purification.

Provenance & Evidence