HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 916659Generated: October 30, 2026
Hydrazine hydrate (1:1) → 2-{4-[2-(3-Fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-hydrazino-pyrimidin-5-yl}-ethanol
https://huagongshe.com/reaction/916659
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Acetic Acid 2-{4-chloro-6-[2-(3-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-pyrimidin-5-yl}-ethyl ester | HCID 57503309 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-{4-[2-(3-Fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-hydrazino-pyrimidin-5-yl}-ethanol | HCID 57503310 | — |
Reaction Steps
A mixture of 163 (1.72 g, 4.6 mmol) and hydrazine monohydrate (0.95 g, 19 mmol) in EtOH (20 mL) is heated at 70° C. overnight. The solvent is removed in vacuo and the residue is triturated with ethyl acetate and ethyl ether. Filtration gives the product (164) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07271170B2 |
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| Source dataset | uspto-grants-2007_09 |
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| ORD ID | ord-8ea3a51c77be49dc89f179bd59fd9de4 |
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| Source note | uspto-grants-2007_09 |
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