Methanol → Methyl 2-chloro-4-nitrobenzoate

HRID 916716Notes

Reaction equation

HRID 916716 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:19]O>>[CH3:19][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:2]=1[Cl:1]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 74482-Chloro-4-nitrobenzoic acid

Product 1

HCID 83343Methyl 2-chloro-4-nitrobenzoate

Procedure

2-Chloro-4-nitrobenzoic acid (50 g, 248 mmol) was subjected to methylation using methanol (500 mL) and H2SO4 (98%, 15 mL) according to the procedure described in the example 66 to obtain the title compound(83)

Workup

  1. customto obtain the title compound(83)

Sources & evidence

ORD record
ord-892ac4fb1d724770b1f3b93a731e4044
Source dataset
uspto-grants-2007_09
Patent number
US07271193B2

Reaction notes

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