Trifluoroacetic acid → HCID 86594785, compound

HRID 916727Notes

Reaction equation

HRID 916727 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[C:15]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=2[C:13]([C:25]#[C:26][CH:27]2[CH2:29][CH2:28]2)([C:21]([F:24])([F:23])[F:22])[O:12][C:11]1=[O:30])(C)(C)C.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>ClCCl>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[NH2:7][CH2:8][CH2:9][N:10]1[C:15]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=2[C:13]([C:25]#[C:26][CH:27]2[CH2:29][CH2:28]2)([C:21]([F:22])([F:24])[F:23])[O:12][C:11]1=[O:30]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69494587HCID 69494587, compound

Product 1

HCID 86594785HCID 86594785, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2.5 mg of 7 was added 500 μL of dichloromethane and 500 μL of trifluoroacetic acid. The mixture was allowed to stir at room temperature for 30 minutes and concentrated under reduced pressure to give 3 mg of 8 as a thick oil (M+H, 359).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-539d548b134e4df889694ce5bedcb328
Source dataset
uspto-grants-2007_09
Patent number
US07271252B2

Reaction notes

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